Composition

Sabroxy® is a powdered bark extract derived from the flowering plant Oroxylum indicum and standardized to 10% Oroxylin A, a unique flavonoid compound which is present in this plant species.

Sabroxy® also contains other unique flavonoid compounds (chrysin, baicalin and baicalein) present in Oroxylum indicum, giving it a broader spectrum of activity.

Sabroxy® is not irradiated or treated with ethylene oxide (EtO), and is also BSE/TSE free. The technical specifications of Sabroxy® are provided in Table.

chemical structure

Chemical structure of Oroxylin A from
Oroxylum indicum sp.

Technical specifications
Botanical/scientific name Oroxylum indicum
CAS no.  Oroxylin A: 480-11-5
Plant part  Bark
Country of origin  India
Organoleptic properties
Appearance Powder
Colour Brown
Contaminants
Total heavy metals (ppm) ≤20
Lead (ppm) ≤3
Residual solvents To comply as per USP
Microbiological properties
Total aerobic microbial count (CFU/g) ≤5000
Total yeast and mould count (CFU/g) ≤100
Escherichia coli Negative/10 g
Salmonella Negative/10 g
Staphylococcus aureus Negative/10 g
Pseudomonas aeruginosa Negative/10 g
Bile-tolerant Gram-negative bacteria Negative/10 g
Shelf-life 2 years

Chemical fingerprinting of Sabroxy® (10% Oroxylum indicum bark extract) shows the presence of characteristic flavonoid compounds, which also helps to distinguish the extract from other plants containing similar compounds such as Scutellaria baicalensis. An HPLC method was developed to identify key differences between these two plants.

sabroxy-graph-01

HPLC chromatogram of Sabroxy®, Oroxylum indicum
aqueous-alcoholic extract

sabroxy-graph-02

HPLC chromatogram of Scutellaria baicalensis
aqueous-alcholic extract