Oroxylum indicum does not induce any toxic reactions in mice

A study was carried out to evaluate the safety of Sabroxy® administration to the liver of the mice. Male C57BL/6J mice were administered with powdered food mixed with Sabroxy (500mg/kg/day) for 4 weeks. After the treatment period, the possibility of hepatotoxicity was assessed by assaying the hepatic health markers in the serum and by liver histology. The results showed that Sabroxy did not affect the total body weight of the mice after 4 weeks of treatment period. Sabroxy treatment did not alter the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin, albumin, globulin and total protein. Also, Sabroxy did not affect the liver histology. Sabroxy was found to be safe upto 500mg/kg/day.

Salamat, Julia M et al., Oroxylum indicum extract does not induce hepatotoxicity in mice. The FASEB Journal. 2020;34(S1):1-1.